Inhibitory Effect of Secretin and Cholecystokinin on Heidenhain Pouch Responses to Gastrin Extract and Histamine.
نویسندگان
چکیده
Rapid intravenous injections of secretin and cholecystokinin (Vitrum) inhibited the acid response of Heidenhain pouch dogs to continuous intravenous gastrin extract. Cholecystokinin caused greater inhibition than secretin. Responses to small doses of histamine were inhibited by cholecystokinin but not by secretin.
منابع مشابه
Inhibitory action of cholecystokinin on acid secretion from Heidenhain pouches induced by endogenous gastrin.
Kosaka and Lim (1930) demonstrated that extracts from the upper intestine would inhibit gastric secretion from dogs with Heidenhain pouches. The degree of inhibition produced was similar to that observed after the oral ingestion of fat. Similar doses of the extract were shown to have no effect on either pancreatic or biliary secretion. Gillespie and Grossman (1964) have demonstrated that cholec...
متن کاملSecretin: the enterogastrone released by acid in the duodenum.
215 (4): 885-888. 1968.-The inhibitory effects of intravenous infusions of secretin and intraduodenal infusions of HCl on gastric secretion were compared in dogs having Heidenhain pouches, gastric and duodenal fistulas. With the gastric fistula open a constant level of secretion was established in the Heidenhain pouch with either gastrin (0.4 or 0.8 g/kg per hr) or histamine dihydrochloride (0....
متن کاملSecretin and cholecystokin / pancreozymin in combination in the inhibition of gastric acid secretion
Inhibition of gastric acid secretion is caused when the mucosa of the upper small intestine is bathed either by fat (Feng, Hou, and Lim, 1929), acid (Sokolov, 1904) or hyperosmolar solutions (Konturek and Grossman, 1965). The studies of Andersson (1960) suggest that the inhibition caused by acid in the duodenum is mediated by a humoral agent. There is therefore interest in the possible inhibito...
متن کاملRelationship between serum gastrin levels and gastric secretion in Heidenhain pouch dogs.
Relationship between serum gastrin levels and gastric secretion was studied in Heidenhain pouch dogs. Bethanecol and tetramethylammonium increased gastric secretion without any significant change in the serum immunoreactive gastrin (IRG) level. Histamine increased gastric secretion but decreased the serum IRG level. Tetragastrin evoked gastric secretion concomitantly with an elevation of the se...
متن کاملPotentiation between Urecholine and Gastrin Extract and between Urecholine and Histamine in the Stimulations of Heidenhain Pouches.
It is frequently said that cholinergic activity, induced either by drugs or by vagal activity, 'potentiates' the acid secretory responses to gastrin or to histamine. The assumption that these combinations of stimuli act in a 'potentiated' rather than an 'additive' fashion is based upon the large augmentations that occur. So far as we have been able to determine, no previous study has provided d...
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عنوان ژورنال:
- Gut
دوره 5 شماره
صفحات -
تاریخ انتشار 1964